
Structure, MOA, uses of warfarin Warfarin is a type of anticoagulant known as a Vitamin K antagonist. Here’s how it works: Inhibition of Vitamin K : Warfarin inhibits the production of reduced from of Vitamin K by blocking the action of an enzyme called Vitamin K oxide reductase . Impact on Clotting Factors : The reduced form of Vitamin K, Vitamin KH2, is a cofactor used in the γ-carboxylation of coagulation factors VII, IX, X, and thrombin . Without sufficient active Vitamin K1, these clotting factors have decreased clotting ability . Resulting Anticoagulant Effect : By inhibiting the reactivation of Vitamin K , Warfarin decreases the synthesis of these clotting factors in the liver, thereby reducing the blood’s ability to clot. USES of WARFARIN - Venous Thromboembolism Treatment of Myocardial infraction Ischemic Attacks Pulmonary embolism