K+ sparing Diuretic



MOA of K+ sparing Diuretic


Aldosterone Receptor Blocker

¯

¯ Expression of Lumen Na channel → ¯ Transport of Na to the Collecting tubule cell

¯ Expression Na/ K ATPase pump → ¯ Transport of Na to Blood (¯ K to the urine)

¯

­ Na and Water in the urine


Uses –

  • Spironolactone is used to treat Hypertension and Heart failure
  • Amiloride used to treat high blood pressure and Heart failure with combination with loop diuretics

Thiazide diuretics 



MOA of Thiazide diuretics 


USES 

  1. Hypertension 
  2. Oedema 
  3. Heart Failure 



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