Structure, MOA, uses of warfarin

Warfarin is a type of anticoagulant known as a Vitamin K antagonist. 






Here’s how it works:

  1. Inhibition of Vitamin K: Warfarin inhibits the production of reduced from of Vitamin K by blocking the action of an enzyme called Vitamin K oxide reductase. 

  2. Impact on Clotting Factors: The reduced form of Vitamin K, Vitamin KH2, is a cofactor used in the γ-carboxylation of coagulation factors VII, IX, X, and thrombin. Without sufficient active Vitamin K1, these clotting factors have decreased clotting ability.

  3. Resulting Anticoagulant Effect: By inhibiting the reactivation of Vitamin K, Warfarin decreases the synthesis of these clotting factors in the liver, thereby reducing the blood’s ability to clot.


USES of WARFARIN -

  1. Venous Thromboembolism 
  2. Treatment of Myocardial infraction 
  3. Ischemic Attacks 
  4. Pulmonary embolism 

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