Structure, moa,uses of any 2 PPIs.

MOA - 

PPIs are taken orally and absorbed into the bloodstream.

¯

The PPIs are transported to the stomach, where they are activated by gastric acid.

¯

The activated PPIs bind covalently to the H+/K+ ATPase proton pump on the surface of parietal cells.

¯

This binding prevents the proton pump from functioning, preventing the secretion of acid into the stomach.

¯

The PPI-bound proton pump complex is eventually degraded, but the PPI remains attached.

¯

This means that the proton pump cannot be repaired or replaced, and acid secretion remains inhibited until new proton pumps are synthesized.

 


Omeprazole


 





Peptic Ulcer

GERD

Zollinger-Ellison syndrome

NSAID induced Acidity



Pantoprazole




Erosive esophagitis (caused by GERD)

Prevention of Stomach ulcer

NSAID induced Acidity



Lansoprazole




 Peptic Ulcer

GERD

Zollinger-Ellison syndrome

NSAID induced Acidity


Comments

Post a Comment

Popular posts from this blog

Classification of anti cancer agents with example Antineoplastic agents are drugs used to treat cancer by killing or stopping the growth of cancer cells.  They can be classified into different types based on their mechanism of action, such as : ALKYLATING AGENTs  Nitrogen Mustards : Chlorambucil   Ethylenimine: Thiotepa    Alkyl sulfonate : Busulfan    Nitrosoureas: Carmustine   Triazine : Dacarbazine   Methyl Hydrazine : Procarbazine    ANTIMETABOLITEs Folate Antagonist : Methotrexate  Purine Antagonist: 6-Mercaptopurine   Pyrimidine Antagonist : 5-Fluorouracil  PLATINUM Co-ODRINATION COMPOUNDs  Example : Carboplatin   ANTICANCER ANTIBIOTICs (Anthracycline)  Example: Doxorubicin & Daunorubicin 
Read more
Image
ANTIMETABOLITES  Antimetabolites are a type of chemotherapy drug that work by interfering with the DNA replication process in cancer cells. They mimic the structure of essential molecules that cancer cells need to replicate their genetic information and prevent them from creating the enzymes they need to divide.  These compounds are known as Antimetabolites because they inhibits the metabolic conversion of certain Chemicals (i.e. Folic Acid) to compounds which are essential for synthesis of DNA (Replication). 
Read more