Structure, moa, uses of cimetidine


Structure of Cimetidine



Mode of Action

Cimetidine Binds with the H2 Receptor (located at gastric parietal cells) competitively and blocks the binding of Histamine to the H2 receptor and decreases the release of Gastric acid (from Proton pump)  by decreasing the conversion of cyclic AMP from ATP inside the Gastric Parietal Cell. 

Uses

  1. Heartburn

  2. Stomach and Duodenal ulcer  

  3. GERD




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