Describe structure, moa, uses of H1 and H2 antagonist (any2) . (5mark)

H2 antagonist 

MOA - 

(a)    Gastrin stimulates the release of histamine from Enterochromaffin like Cell.

(b)   Then Histamine binds with H2 Receptor of Gastric Parietal cell

(c)    Binding of Histamine to H2 receptor increases the intracellular cyclic AMP and activates Protein Kinase A

(d)   PKA stimulates the release of Gastric acid by the H+/K+ATPase pump (proton pump).

(e)    Competitively and reversibly blocking the H2 receptor we can supress the release of Gastric Acid secretion induced by Histamine.  



Drugs

Structure

Uses

Cimetidine



Heartburn

GERD

Stomach and Duodenal ulcer 


Ranitidine



Zollinger-Ellison Syndrome

Gastroesophageal Reflex Disease

Peptic Ulcer


Famotidine



Zollinger-Ellison Syndrome

GERD

Heartburn



 

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