Outline the synthesis of promethazine. Structure, moa, uses of 1st gen. (Any 2) and 2nd gen. H1 antagonist (any 2) (10 mark)

Synthesis of Promethazine 





H1 Antagonist (1st gen) 
(a) Chlorpheniramine Malate

Uses- symptoms of allergic reactions; over-the-counter products for cold; depression, nausea and vomiting, motion sickness, and vertigo.

(b) Diphenhydramine

Uses: Allergic reaction, Motion sickness; Insomnia, Cough, Nausea 

H1 Antagonists (2nd Gen) 

(a) Cetirizine

USES: Allergic Rhinitis; Chronic hives 

(b) Loratadine

Uses: Allergic Rhinitis; Chronic hives 

Mechanism of Action 








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