Synthesis of Nitroglycerine
General structural features of 1st gen. H1 antagonist. Structure moa, uses of chlorpheniramine maleate, promethazine hydrochloride , doxylamine succinate . General Structure of H1 Antagonists Aryl group: The diaryl substitution is essential for significant H1-receptor affinity. The optimal antihistaminic activity depends upon the co-planarity of two aryl substitutions . Nature of ‘X’: The X-connecting moiety of H1-antihistamines may be a simple carbon chain or saturated carbon-oxygen moiety, which serves as a spacer group for the required pharmacophore . Alkyl chain (The carbon chain): The carbon chain consists of two or three atoms in H1-antihistamines . Terminal Nitrogen : This is a basic, terminal amine functional group . Contains small alkyl substituting. Promethazine USES - Allergic reaction, Motion sickness Insomnia, Cough, Nausea chlorpheniramine maleate USES- symptoms of allergic reactions;...
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