Classification of Local Anesthetics


 General MOA of LAs 

  1. Local Anaesthetic Crosses the biological membrane, and gets ionised.
  2. Ionised form of LA can bind with the LA receptor located at the intracellular part
  3. Binding of LA to its receptor stabilizes the channel in the inactivated state, inactivated gate closes, No Na+ ion can flow inside
  4. Prevention of Depolarization of at the time of Action potential generation.
  5. No Action potential Generated → Loss of Sensation 



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