General Structural Features of LAs 

Aryl Group (lipophilic portion) –

*       The aryl group is the most important functional group for the lipophilicity of LA. Aryl group helps the LA to cross the cell membrane.

Bridge/intermediate linker – (Ester/amide/thioester/thioamide)

*       The intermediate bridge can be C, O, N or S. It helps to connect the lipophilic and hydrophilic Parts. 

Hydrophilic Portion (Aminoalkyl group) –

*       Aminoalkyl group is not necessary for LA action but is important for the formation of water-soluble salts.



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