Procaine 



Mode of Action:

  •  Local Anaesthetic Crosses the biological membrane, and gets ionised
  • Ionised form of LA can bind with the LA receptor located at the intracellular part
  • Binding of LA to its receptor stabilizes the channel in the inactivated state, inactivated gate closes, No Na+ ion can flow inside.
  • Prevention of Depolarization of at the time of Action potential generation.
  • No Action potential Generated → Loss of Sensation 



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