Procaine 



Mode of Action:

  •  Local Anaesthetic Crosses the biological membrane, and gets ionised
  • Ionised form of LA can bind with the LA receptor located at the intracellular part
  • Binding of LA to its receptor stabilizes the channel in the inactivated state, inactivated gate closes, No Na+ ion can flow inside.
  • Prevention of Depolarization of at the time of Action potential generation.
  • No Action potential Generated → Loss of Sensation 



Comments

Post a Comment

Popular posts from this blog

Classification of anti cancer agents with example Antineoplastic agents are drugs used to treat cancer by killing or stopping the growth of cancer cells.  They can be classified into different types based on their mechanism of action, such as : ALKYLATING AGENTs  Nitrogen Mustards : Chlorambucil   Ethylenimine: Thiotepa    Alkyl sulfonate : Busulfan    Nitrosoureas: Carmustine   Triazine : Dacarbazine   Methyl Hydrazine : Procarbazine    ANTIMETABOLITEs Folate Antagonist : Methotrexate  Purine Antagonist: 6-Mercaptopurine   Pyrimidine Antagonist : 5-Fluorouracil  PLATINUM Co-ODRINATION COMPOUNDs  Example : Carboplatin   ANTICANCER ANTIBIOTICs (Anthracycline)  Example: Doxorubicin & Daunorubicin 
Read more
Image
General structural features of 1st gen. H1 antagonist. Structure moa, uses of chlorpheniramine maleate, promethazine hydrochloride , doxylamine succinate . General Structure of H1 Antagonists Aryl group: The diaryl substitution is essential for significant H1-receptor affinity.  The optimal antihistaminic activity depends upon the co-planarity of two aryl substitutions . Nature of ‘X’: The X-connecting moiety of H1-antihistamines may be a simple carbon chain or saturated carbon-oxygen moiety, which serves as a spacer group for the required pharmacophore . Alkyl chain (The carbon chain): The carbon chain consists of two or three atoms in H1-antihistamines . Terminal Nitrogen : This is a basic, terminal amine functional group . Contains small alkyl substituting.  Promethazine  USES -  Allergic reaction, Motion sickness Insomnia, Cough, Nausea  chlorpheniramine maleate USES-  symptoms of allergic reactions;...
Read more
Image
  K +  sparing Diuretic MOA of K + sparing Diuretic Aldosterone Receptor Blocker ¯ ¯ Expression of Lumen Na channel → ¯ Transport of Na to the Collecting tubule cell ¯ Expression Na/ K ATPase pump → ¯ Transport of Na to Blood ( ¯ K to the urine) ¯ ­ Na and Water in the urine Uses – Spironolactone is used to treat Hypertension and Heart failure Amiloride used to treat high blood pressure and Heart failure with combination with loop diuretics Thiazide diuretics  MOA of Thiazide diuretics  USES  Hypertension  Oedema  Heart Failure 
Read more